HCC module 414. Module 414 shows interactions among MAPK, DUSP genes and FOSB and JUNB oncogenes. The DUSP family of genes is known to regulate the activity of MAP kinases, a number of which play a role in cancer. This module presents interactions among MAPK genes and the oncogene JUNB, protooncogene FOSB, and RIPK2. RIPK2 is not well-described, but appears to play a role in apoptosis. Red nodes designate cancer-associated genes based on descriptions in OMIM. Node sizes correspond to the absolute values of the fold change of differentially regulated genes (up- or down-regulated). Blue edges are derived from HPRD, green from KEGG, and orange from both databases.