Figure 4
From: Using random walks to identify cancer-associated modules in expression data
HCC module 414. Module 414 shows interactions among MAPK, DUSP genes and FOSB and JUNB oncogenes. The DUSP family of genes is known to regulate the activity of MAP kinases, a number of which play a role in cancer. This module presents interactions among MAPK genes and the oncogene JUNB, protooncogene FOSB, and RIPK2. RIPK2 is not well-described, but appears to play a role in apoptosis. Red nodes designate cancer-associated genes based on descriptions in OMIM. Node sizes correspond to the absolute values of the fold change of differentially regulated genes (up- or down-regulated). Blue edges are derived from HPRD, green from KEGG, and orange from both databases.