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Table 2 miRNA target genes KEGG pathway enrichment

From: MicroRNA-mediated regulation of target genes in several brain regions is correlated to both microRNA-targeting-specific promoter methylation and differential microRNA expression

  

CRBLM

CRBLM

CRBLM

FCTX

FCTX

PONS

  

vs

vs

vs

vs

vs

vs

  

FCTX

PONS

TCTX

PONS

TCTX

TCTX

 

KEGG pathways

R

N

R

N

R

N

R

N

R

N

R

N

   1

TGF- β signaling pathway

   

  

 

   2

Glioma

  

    

   3

MAPK signaling pathway

     

  

   4

Axon guidance

        

   5

Phosphatidylinositol signaling system

 

        

   6

mTOR signaling pathway

         

   7

Adipocytokine signaling pathway

 

 

      

   8

Pancreatic cancer

 

   

    

   9

Endocytosis

      

 

10

Focal adhesion

      

 

11

Insulin signaling pathway

        

12

Neurotrophin signaling pathway

        

13

Colorectal cancer

        

14

Arrhythmogenic right ventricular cardiomyopathy (ARVC)

     

  

15

Wnt signaling pathway

 

   

  

16

Non-small cell lung cancer

          

17

Adherens junction

      

 

18

ErbB signaling pathway

        

19

Pathways in cancer

   

  

 

20

Glycosaminoglycan biosynthesis - heparan sulfate

   

   

21

Type II diabetes mellitus

          

22

Melanoma

 

   

    

23

Renal cell carcinoma

        

24

Inositol phosphate metabolism

          

25

Chronic myeloid leukemia

   

    

26

T cell receptor signaling pathway

          

27

Small cell lung cancer

         

28

Fc gamma R-mediated phagocytosis

 

        

29

Prostate cancer

         

30

Salivary secretion

          

31

Osteoclast differentiation

          

32

Regulation of actin cytoskeleton

        

33

Endocrine and other factor-regulated calcium reabsorption

          

34

Lysine degradation

  

 

      

35

Circadian rhythm - mammal

  

   

 

  

36

Glycosaminoglycan biosynthesis - chondroitin sulfate

  

    

   

37

N-Glycan biosynthesis

  

        

38

Long-term depression

   

   

    

39

Prion diseases

   

      

 

40

ECM-receptor interaction

  

     

   

41

Tight junction

   

     

  

42

Hypertrophic cardiomyopathy (HCM)

   

     

  

43

Cell adhesion molecules (CAMs)

     

     

44

Dilated cardiomyopathy

   

     

  

45

Fatty acid biosynthesis

           

46

Long-term potentation

  

         

47

Ubiquitin mediated proteolysis

  

         

48

Thyroid cancer

  

         

49

Notch signaling pathway

  

         

50

Mismatch repair

  

         

51

Acute myeloid leukemia

  

         

52

Glycosphingolipid biosynthesis - lacto and neolacto series

  

         

53

Glycosaminoglycan biosynthesis - keratan sulfate

   

        

54

Biotin metabolism

   

        

55

Gap junction

   

        

56

Gastric acid secretion

   

        

57

Taurine and hypotaurine metabolism

   

        

58

Aldosterone-regulated sodium reabsorption

   

        

59

GnRH signaling pathway

   

        

60

Metabolism of xenobiotics by cytochrome P450

     

      

61

Mucin type O-Glycan biosynthesis

       

    

62

Biosynthesis of unsaturated fatty acids

        

   

63

Viral myocarditis

         

  

64

Cytokine-cytokine receptor interaction

          

 

65

Hematopoietic cell lineage

          

 

66

Valine, leucine and isoleucine biosynthesis

           

  1. KEGG pathways marked with are enriched by target genes of miRNAs selected in Table 1. “R” and “N” indicate whether the relationship between miRNA expression and target gene mRNA is reciprocal (nonreciprocal). Pathways asterisked and bold faced are directly related to brain and neurons, respectively, and discussed in detail in the Supplementary Document (see Additional file 1).