Table 3 Power and type I error assessment
A) Only Locus1*2 has an interaction | Model 1 (n=300) | Model 2 (n=300) | Model 3 (n=300) | Model 4 (n=300) | ||||
|---|---|---|---|---|---|---|---|---|
Power | Type I | Power | Type I | Power | Type I | Power | Type I | |
A-MDR pOR | 1 | 0.01 | 1 | 0.01 | 0.75 | 0.01 | 1 | 0.03 |
A-MDR pRR | 1 | 0 | 1 | 0.01 | 0.71 | 0.01 | 1 | 0.03 |
A-MDR pChi | 1 | 0.01 | 1 | 0 | 0.86 | 0.03 | 1 | 0 |
MDR | 1 | 0 | 1 | 0 | 0.46 | 0.02 | 1 | 0 |
A) Only Locus1*2 has an interaction | Model 1 (n=400) | Model 2 (n=400) | Model 3 (n=400) | Model 4 (n=400) | ||||
Power | Type I | Power | Type I | Power | Type I | Power | Type I | |
A-MDR pOR | 1 | 0 | 1 | 0 | 0.86 | 0 | 1 | 0.02 |
A-MDR pRR | 1 | 0 | 1 | 0 | 0.87 | 0 | 1 | 0.03 |
A-MDR pChi | 1 | 0.02 | 1 | 0.01 | 0.95 | 0.01 | 1 | 0.02 |
MDR | 1 | 0 | 1 | 0 | 0.68 | 0.01 | 1 | 0 |
B) Genetic heterogeneity γ 1 = γ 2 =0.5 | Model 1 | Model 2 | Model 1 | Model 2 | Model 3 | Model 4 | Model 3 | Model 4 |
n=400 Power | n=800 Power | n=400 Power | n=800 Power | |||||
A-MDR pOR | 0.98 | 1 | 1 | 1 | 0.37 | 0.91 | 0.7 | 1 |
A-MDR pRR | 0.99 | 1 | 1 | 1 | 0.35 | 0.78 | 0.68 | 1 |
A-MDR pChi | 0.99 | 1 | 1 | 1 | 0.31 | 0.99 | 0.72 | 1 |
MDR | 0.12 | 0.75 | 0.08 | 0.78 | 0 | 0.69 | 0 | 0.92 |
B) Genetic heterogeneity γ 1 =0.7,γ 2 =0.3 | Model 1 | Model 2 | Model 1 | Model 2 | Model 3 | Model 4 | Model 3 | Model 4 |
n=400 Power | n=800 Power | n=400 Power | n=800 Power | |||||
A-MDR pOR | 1 | 0.35 | 1 | 0.98 | 0.55 | 0.35 | 0.92 | 0.78 |
A-MDR pRR | 1 | 0.25 | 1 | 0.97 | 0.55 | 0.3 | 0.91 | 0.74 |
A-MDR pChi | 1 | 0.5 | 1 | 0.99 | 0.6 | 0.49 | 0.96 | 0.86 |
MDR | 1 | 0 | 0.99 | 0 | 0.14 | 0.21 | 0.14 | 0.38 |
C) Additive Models | Model 1 | Model 2 | Model 1 | Model 2 | Model 3 | Model 4 | Model 3 | Model 4 |
n=400 Power | n=800 Power | n=400 Power | n=800 Power | |||||
A-MDR pOR | 1 | 0.72 | 1 | 1 | 0.6 | 0.16 | 0.93 | 0.61 |
A-MDR pRR | 1 | 0.69 | 1 | 0.98 | 0.61 | 0.14 | 0.91 | 0.55 |
A-MDR pChi | 1 | 0.79 | 1 | 1 | 0.71 | 0.29 | 0.98 | 0.76 |
MDR | 0.91 | 0.02 | 0.99 | 0.01 | 0.26 | 0.14 | 0.43 | 0.12 |