Figure 5
Gene to gene interaction detected by MDR after filtering out 6 SNPs according to the one sided inverse chi-square test. (The distribution of MTXglu clustering among genotypic combinations between DHFR-rs7387 and ITPA-rs2295553 is listed. The genotype for DHFR-rs7387 and ITPA-rs2295553 is coded as 0-homozygote, 1-heterozygote and 2-rare homozygote. In each cell, the first column stands for the number of subjects in cluster 1 (low concentration of MTXglu1-2% and high concentration of MTXglu3-4%) and the second column stands for the number of subjects in cluster 2(high concentration of MTXglu1-2% and low concentration of MTXglu3-5%. Genotypic combinations in relatively high (low) likelihood of cluster 1 are displayed in darkly (lightly) shaded cells).