TY - JOUR AU - Brown, Chad C. AU - Havener, Tammy M. AU - Medina, Marisa Wong AU - Krauss, Ronald M. AU - McLeod, Howard L. AU - Motsinger‐Reif, Alison A. PY - 2012 DA - 2012/12/12 TI - Multivariate methods and software for association mapping in dose‐response genome‐wide association studies JO - BioData Mining SP - 21 VL - 5 IS - 1 AB - The large sample sizes, freedom of ethical restrictions and ease of repeated measurements make cytotoxicity assays of immortalized lymphoblastoid cell lines a powerful new in vitro method in pharmacogenomics research. However, previous studies may have over‐simplified the complex differences in dose‐response profiles between genotypes, resulting in a loss of power. SN - 1756-0381 UR - https://doi.org/10.1186/1756-0381-5-21 DO - 10.1186/1756-0381-5-21 ID - Brown2012 ER -