Table 1 Top 10 KEGG pathways associated with 662 miRNA targets theoretically upregulated in AD brains

1

hsa05200:Pathways in cancer

ACVR1B, ACVR1C, AKT1, APC, BCL2, BCR, CASP3, CCND1, CCNE1, CCNE2, CDK6, CDKN1A, CDKN1B, CDKN2A, CEBPA, CTNNB1, CUL2, E2F1, E2F3, EGFR, EP300, EPAS1, ERBB2, ETS1, FGF13, FGF2, FGFR1, FH, FLT3, FOS, FOXO1, HGF, HIF1A, HRAS, IL6, ITGA2, ITGA2B, JUN, KRAS, LAMC1, MAP2K1, MAPK8, MAPK9, MET, MMP9, MTOR, MYC, PDGFA, PIAS1, PIK3CA, PML, PPARG, PRKCA, PTEN, PTGS2, RARA, RASSF1, RUNX1, RXRA, SHH, SMAD2, SMAD3, SMAD4, STAT1, STAT3, TGFB1, TGFBR1, TGFBR2, TP53, TPM3, VEGFA, WNT5A, XIAP

2.84E-21

2.20E-20

2

hsa05212:Pancreatic cancer

ACVR1B, ACVR1C, AKT1, CCND1, CDK6, CDKN2A, E2F1, E2F3, EGFR, ERBB2, KRAS, MAP2K1, MAPK8, MAPK9, PIK3CA, SMAD2, SMAD3, SMAD4, STAT1, STAT3, TGFB1, TGFBR1, TGFBR2, TP53, VEGFA

3.06E-10

2.37E-09

3

hsa05210:Colorectal cancer

ACVR1B, ACVR1C, AKT1, APC, BCL2, CASP3, CCND1, CTNNB1, EGFR, FOS, JUN, KRAS, MAP2K1, MAPK8, MAPK9, MET, MYC, PIK3CA, SMAD2, SMAD3, SMAD4, TGFB1, TGFBR1, TGFBR2, TP53

1.25E-08

9.70E-08

4

hsa05220:Chronic myeloid leukemia

ACVR1B, ACVR1C, AKT1, BCR, CCND1, CDK6, CDKN1A, CDKN1B, CDKN2A, E2F1, E2F3, HRAS, KRAS, MAP2K1, MYC, PIK3CA, RUNX1, SMAD3, SMAD4, TGFB1, TGFBR1, TGFBR2, TP53

4.51E-08

3.50E-07

5

hsa05215:Prostate cancer

AKT1, BCL2, CCND1, CCNE1, CCNE2, CDKN1A, CDKN1B, CREB1, CTNNB1, E2F1, E2F3, EGFR, EP300, ERBB2, FGFR1, FOCO1, HRAS, KRAS, MAP2K1, MTOR, PDGFA, PIK3CA, PTEN, TP53

2.83E-07

2.19E-06

6

hsa05219:Bladder cancer

CCND1, CDKN1A, CDKN2A, E2F1, E2F3, EGFR, ERBB2, HRAS, KRAS, MAP2K1, MMP9, MYC, RASSF1, THBS1, TP53, VEGFA

1.66E-06

1.29E-05

7

hsa05218:Melanoma

AKT1, CCND1, CDK6, CDKN1A, CDKN2A, E2F1, E2F3, EGFR, FGF13, FGF2, FGFR1, HGF, HRAS, KRAS, MAP2K1, MET, PDGFA, PIK3CA, PTEN, TP53

4.12E-06

3.19E-05

8

hsa04010:MAPK signaling pathway

ACVR1B, ACVR1C, AKT1, ATF2, BDNF, CACNA1C, CACNA2D1, CACNB1, CASP3, DUSP1, DUSP16, EGFR, FGF13, FGF2, FGFR1, FOS, GADD45A, HRAS, HSPA1A, HSPA1B, JUN, KRAS, MAP2K1, MAP3K12, MAPK14, MAPK8, MAPK9, MAPKSP1, MEF2C, MYC, NLK, PDGFA, PPP3CA, PPP3R1, PPP5C, PRKCA, RASA1, STMN1, TGFB1, TGFBR1, TGFBR2, TP53

1.17E-05

9.03E-05

9

hsa04110:Cell cycle

ATM, CCND1, CCND2, CCND3, CCNE1, CCNE2, CDC14A, CDC25A, CDK6, CDKN1A, CDKN1B, CDKN2A, CHEK1, E2F1, E2F3, EP300, GADD45A, MYC, PLK1, SMAD2, SMAD3, SMAD4, TGFB1, TP53, TTK, WEE1

1.51E-05

1.17E-04

10

hsa05214:Glioma

AKT1, CAMK2G, CCND1, CDK6, CDKN1A, CDKN2A, E2F1, E2F3, EGFR, HRAS, KRAS, MAP2K1, MTOR, PDGFA, PIK3CA, PRKCA, PTEN, TP53

1.99E-05

1.54E-04