Figure 6

MicroRNA targetome shows a significant relationship with infection and cancer-related network in ATL cells. The set of 932 targets for 24 downregluated miRNAs in ATL cells versus normal CD4⁺ T cells (GSE31629) were imported into the Core Analysis tool of IPA in the display setting of 70 molecules per network. The first rank molecular network defined by “Infectious Disease, Protein Synthesis, Cancer” (p = 1.00E-82) is shown in the subcellular location layout. The red nodes represent the genes theoretically upregulated in ATL cells.