Figure 4
From: Molecular network analysis of human microRNA targetome: from cancers to Alzheimer’s disease
Differentially expressed microRNAs separate the cluster of ATL cells from normal CD4 + T cells. We studied the dataset GSE31629 that contains miRNA expression profiling of peripheral blood mononuclear cells (PBMC) derived form ATL patients (n = 40) and CD4+ T cells from healthy control subjects (n = 22). Hierarchical clustering analysis of the set of 4 upregulated and 24 downregulated miRNAs in ATL cells versus normal CD4+ T cells separated the cluster of ATL samples from the cluster of normal CD4+ T cells. Hierarchical clustering analysis was performed by using Cluster 3.0 (bonsai.ims.u-tokyo.ac.jp/~mdehoon/software/cluster) and TreeView 1.1.5r2 (sourceforge.net/projects/jtreeview).