Comparison of gene expression similarities based on AGEP analysis of seven samples representing various differentiation and/or malignancy states of myeloid cells (hematopoietic stem cells, leukemic stem cells, myeloblasts, monoblasts, AML, granulocytes and monocytes). For each sample, the number of tissue specific (ts-score >0.75) genes for the three reference tissue types (hematopoietic stem cell, bone marrow granulocyte, blood monocyte) is shown as bar charts. There is a gradual change in the transcriptomic program when moving from hematopoietic stem cells to the most differentiated granulocytes and monocytes as well as to malignant AML cells. As expected, the hematopoietic stem cell sample had several genes specific to the HSC reference cell type, while in the myeloblast sample this number is much lower. The myeloblast sample did not express monocyte or granulocyte specific genes. Leukemic stem cells have some HSC specific expression, while the AML resembles slightly more the granulocyte reference than the HSC or monocyte reference.