Figure 3
From: DA DA: Degree-Aware Algorithms for Network-Based Disease Gene Prioritization
Statistical adjustment based on seed degrees. First, the association score of a candidate with respect to the original seed set is computed. After generating a large number of random seed sets that represent the original set in terms of the degree distribution and size, association score of the candidate is computed using each of these random sets separately. Adjusted score of the candidate protein is then calculated as the statistical significance of the original association score, using this random population of association scores.