Table 2 Results of data mining on RA and CHD in PubMed and SinoMed with Chinese herbs Safflower and Astragalus

Safflower

Inflammation

Apoptosis

Proto-Oncogene Proteins c-bcl-2, Caspase 3, bcl-2- Associated × Protein, Caspases, Nitric Oxide Synthase, Prostaglandin-Endoperoxide Synthases, Vascular Endothelial Growth Factors

Leukocytes

Interleukin-2, Leukotriene B4, Linoleic Acid, Throm-boxane B2, Triglycerides

Monocytes

Interleukin-1, Tumor Necrosis Factor-alpha, Interleukin-6, NF-kappa B, Intercellular Adhesion Molecule-1

Cytokines

Interleukin-6, Tumor Necrosis Factor-alpha, Interleukin-1, Interleukin-10, Thromboxane B2, 6-Ketoprostaglandin F1 alpha, Cyclooxygenase 1, Cyclooxygenase 2, Leukotriene B4, NF-kappa B, Prostaglandin-Endoperoxide Synthases, Toll-Like Receptor 4

Macrophages

Eicosapentaenoic Acid, Interleukin-2, Prostaglandins E, Tumor Necrosis Factor-alpha, Interleukin-1, Leukotriene B4, Endothelial Growth Factors, Prostaglandin-Endoperoxide Synthases, Thromboxane B2, Vascular Endothelial Growth Factor A, Vascular Endothelial Growth Factors

Astragalus

Inflammation

Apoptosis

Caspase 3, Tumor Necrosis Factor-alpha, Caspases, NF-kappa B, Proto-Oncogene Proteins c-bcl-2, bcl-2-Associated × Protein, Interleukin-10, Interleukin-6, Nitric Oxide Synthase Type II, Transforming Growth Factor beta1, Tumor Suppressor Protein p53

Leukocytes

Cyclooxygenase 1, E-Selectin, Intercellular Adhesion Molecule-1, NF-kappa B, Phospholipases A, Tumor Necrosis Factor-alpha

Monocytes

Tumor Necrosis Factor-alpha

Cytokines

Interleukin-2, Interleukin-10, Interleukin-6, Interleukin-1, Interleukin-8, Matrix Metalloproteinase 9, Toll-Like Receptor 4, Transforming Growth Factor beta1, Tumor Necrosis Factor-alpha, Vascular Endothelial Growth Factor A

Macrophages

Interleukin-1, Interleukin-2, NF-kappa B, Toll-Like Receptor 4