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Table 1 Sensitivity of MDR to detect one-locus disease models

From: The effects of linkage disequilibrium in large scale SNP datasets for MDR

Scenario Relative LD Effect Size Exact Sensitivity Signal Sensitivity Signal Sensitivity when Functional SNP Dropped
SNP at Edge of LD Block 40% 1.5 OR 86 87 4
   2.0 OR 96 96 7
   3.0 OR 94 94 10
  60% 1.5 OR 85 93 71
   2.0 OR 97 99 67
   3.0 OR 96 96 49
  80% 1.5 OR 23 90 90
   2.0 OR 22 91 91
   3.0 OR 28 92 92
  95% 1.5 OR 14 82 84
   2.0 OR 25 90 90
   3.0 OR 24 94 95
SNP in Middle of LD Block 40% 1.5 OR 76 80 14
   2.0 OR 92 92 10
   3.0 OR 95 95 5
  60% 1.5 OR 58 90 92
   2.0 OR 75 99 99
   3.0 OR 73 93 94
  80% 1.5 OR 54 88 87
   2.0 OR 72 93 96
   3.0 OR 84 94 93
  95% 1.5 OR 0 92 92
   2.0 OR 0 83 83
   3.0 OR 0 93 93
  1. The exact sensitivity, signal sensitivity and sensitivity with functional SNP removed, for MDR to identify a disease signal in data with 40% to 95% LD under two one-locus scenarios.