TY - JOUR AU - Shameer, Khader AU - Nagarajan, Paramasivam AU - Gaurav, Kumar AU - Sowdhamini, Ramanathan PY - 2009 DA - 2009/12/04 TI - 3PFDB - A database of Best Representative PSSM Profiles (BRPs) of Protein Families generated using a novel data mining approach JO - BioData Mining SP - 8 VL - 2 IS - 1 AB - Protein families could be related to each other at broad levels that group them as superfamilies. These relationships are harder to detect at the sequence level due to high evolutionary divergence. Sequence searches are strongly directed and influenced by the best representatives of families that are viewed as starting points. PSSMs are useful approximations and mathematical representations of protein alignments, with wide array of applications in bioinformatics approaches like remote homology detection, protein family analysis, detection of new members and evolutionary modelling. Computational intensive searches have been performed using the neural network based sensitive sequence search method called FASSM to identify the Best Representative PSSMs for families reported in Pfam database version 22. SN - 1756-0381 UR - https://doi.org/10.1186/1756-0381-2-8 DO - 10.1186/1756-0381-2-8 ID - Shameer2009 ER -