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Table 2 Contingency table underlying the guilt-by-association algorithm

From: Mining tissue specificity, gene connectivity and disease association to reveal a set of genes that modify the action of disease causing genes

Disease Associated?

Number of Connections

% Disease-associated genes among interactors

  

≤ 75

> 75

Yes

≤ 12

3,112

1,907

 

> 12

481

651

No

≤ 12

7,853

705

 

> 12

229

112

  1. Number of disease- and non-disease-associated genes by thresholds on number of connections and percentage of disease-associated genes among interactors. The thresholds are obtained from exploring disease-associated genes and correspond to the average number of connections (12) among disease-associated genes and the average proportion of disease-associated genes (75%) among their interactors. The 112 non-disease-associated genes (bottom right cell) form the basis of the newly reported disease-associated genes [see Additional file 2].