Mining tissue specificity, gene connectivity and disease association to reveal a set of genes that modify the action of disease causing genes

Table 1 Relationship between the number of tissues in which a gene is expressed and a series of variables.

Variable	Correlation	Regression
Expression:
Overall genes	0.706	2.034
Non-Interacting (NI) genes only	0.709	1.802
Interacting genes only	0.707	2.107
Non-Disease (ND)	0.707	1.769
Disease (D)	0.709	2.382
Non-Interacting and Non-Disease	0.691	1.759
Non-Interacting and Disease	0.764	2.039
Interacting and Non-Disease	0.719	1.803
Interacting and Disease	0.702	2.438
Proportion of interacting genes:
Overall genes	0.949	0.012
Non-Disease genes only	0.942	0.013
Disease genes only	0.917	0.008
Proportion of disease genes:
Overall	0.527	0.002
Non-Interacting genes only	-0.263	-0.001
Interacting genes only	-0.733	-0.004
Tissue specificity of interactors:
Overall genes	0.887	0.112
Non-Disease genes only	0.736	0.062
Disease genes only	0.872	0.151
Proportion of disease genes among interactors:
Overall genes	0.229	0.000
Non-Disease genes only	-0.048	0.000
Disease genes only	0.575	0.001

ISSN: 1756-0381