Uncovering mechanisms of transcriptional regulations by systematic mining of cis regulatory elements with gene expression profiles

Table 5 Significant transcriptional factors identified by the two-tailed non-parametric

Motif	Occurrence Number	p-value	q-value	Transcription Factors
NKTSSCGC	161	4.28E-12	7.49E-10	E2F1
RACCACGTGCTC	575	3.92E-08	3.43E-06	MYC/MAX
ARATKGAST	15	1.97E-06	0.000115	FOXM1
RGCAGSTG	15	4.79E-06	0.00021	MYOGENIN
VTGAACTTTGMMB	1217	4.24E-05	0.00149	HNF4ALPHA
AGATADMAGGGA	19	0.000158	0.00462	GATA4
ATGCCCATATATGGWNNT	111	0.000203	0.00507	SRF
TWSGCGCGAAAAYKR	10	0.000247	0.00514	E2F
TRRCCAATSRN	159	0.000264	0.00514	NFY
NNCCACGTGNNN	15	0.000495	0.00867	NMYC
CTCTAAAAATAACYCY	14	0.000618	0.00984	MEF2
GGTACAANNTGTYCTK	55	7.00E-04	0.0102	GRE
NBTGGGTGGTCN	15	0.00191	0.023	GLI
RRCAGGTGNCV	27	0.00197	0.023	E12
ACAAGATAA	7	0.00269	0.0288	EVI1

Mann-Whitney rank sum tests from Day 1 to Day 2
Significant transcriptional factors identified by the two-tailed non-parametric Mann-Whitney rank sum tests
from Day 1 to Day 2. The Motif column shows the consensus binding site sequence for the transcriptional factor. The second column lists the total number genes containing that that transcriptional factor binding sites in the promoter regions. The p-value column illustrates the two-tailed Mann-Whitney rank sum p-value. The q-value column shows the multiple testing corrected FDR q-value. The transcriptional factor column lists the name of the transcriptional factor which is known to bind to that motif. The total number of Refseq genes with raw expression levels at least 100 in either Day 1 or Day 2 is 7066.

ISSN: 1756-0381