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Table 3 Significant synergistic transcriptional factors in down-regulated genes from Day 1 to Day 2

From: Uncovering mechanisms of transcriptional regulations by systematic mining of cis regulatory elements with gene expression profiles

Motif Occurrence Number p-value q-value Transcription Factors
RACCACGTGCTC_GGGRATTTCC 17 0.00105 0.0122 CMYC NFKAPPAB65
HWAAATCAATAW_TRRCCAATSRN 4 0.0028 0.0122 HNF6 NFY
GCCNNNRGS_ACWTCCK 3 0.00304 0.0122 AP2ALPHA PEA3
AGWACATNWTGTTCT_SGGRNTTTCC 3 0.00523 0.0157 AR CREL
AGACNBCNN_ASMCTTGGGSRGGG 2 0.00859 0.0189 SMAD SP3
  1. Significant synergistic transcriptional factors in down-regulated genes from Day 1 to Day 2. The Motif column shows the consensus binding site sequence for the transcriptional factor where two motifs are separated by an underscore. The second column lists the total occurrence number of genes containing that motif in the promoter regions. The p-value column illustrates the Mann-Whitney rank sum p-value. The q-value column shows the multiple testing corrected FDR q-value. The last column lists the name of the transcription factors. The total number of down-regulated Refseq genes with raw expression levels at least 100 in Day 1 is 3728.