Modeling gene-by-environment interaction in comorbid depression with alcohol use disorders via an integrated bioinformatics approach

Table 6 Additional hypotheses tested based on GeneGo modelling

Short form, PubMed Queries	# PubMed Citations
depression AND CBS	1
ethanol AND CBS	2
depression AND ethanol AND CBS	0
depression AND BHMT	0
ethanol AND BHMT	6
depression AND ethanol AND BHMT	0
depression AND SHMT	0
ethanol AND SHMT	0
depression AND ethanol AND SHMT	0
depression AND MTR	1
ethanol AND MTR	17
depression AND ethanol AND MTR	0
depression AND folate	133
ethanol AND folate	237
depression AND ethanol AND folate	0
depression AND p53	0
ethanol AND p53	43
depression AND ethanol AND p53	0
depression AND HNF4a	0
ethanol AND HNF4a	0
depression AND ethanol AND HNF4a	0

Based on GeneGo modelling, additional candidate genes were tested for association with depression, AUD, and the comorbidity on 9 December, 2007. As in Table 2, queries were qualified by Medical Subject Headings (MeSH) annotation to minimize spurious associations. The actual queries, including MeSH qualification, are provided as Additional Materials (Tables_2_and_6_Detailed.xls). Column 1 has a short form of the query and column 2 shows the number of citations that meet the query criteria.