Modeling gene-by-environment interaction in comorbid depression with alcohol use disorders via an integrated bioinformatics approach

Table 4 Significant biomedical keywords identified by PDG-ACE across the TNF/MTHFR gene pair, and relevance to depression with AUD

*Keyword*	# PubMed citations for query:
Ethanol	263
Consumption	29
Background	12
Intake	10
Child	9
Mortality	6
Transplant	2
Mineral	1
Hemodialysis	0
Abdominal	0
Carotid	0
Wall	0
Preoperative	0
Lumbar	0
kidney transplantation	0
Spine	0
Homozygote	0
Mediterranean	0
hormone replacement therapy	0
p53 gene	0
Sickle	0

Each keyword derived from the PDG-ACE analysis (column 1) was queried against the PubMed database via the query: ("Depressive Disorder" [Mesh] OR "Depression" [Mesh] OR "Depressive Disorder, Major" [Mesh]) AND ("Ethanol" [Mesh] OR "Alcohol-Induced Disorders, Nervous System" [Mesh]) AND Keyword. Citation counts are used as an indication of the keyword's relevance in comorbid depression with AUD.

ISSN: 1756-0381