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Figure 4 | BioData Mining

Figure 4

From: Modeling gene-by-environment interaction in comorbid depression with alcohol use disorders via an integrated bioinformatics approach

Figure 4

GeneGo graphic illustrating how TNF signaling impacts one-carbon metabolism. Folate metabolism is one element of one-carbon metabolism and TNF signaling influences all of the enzymes involved. As a result, variations in any of the genes involved in one-carbon metabolism could influence folate metabolism and susceptibility to depression.

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ISSN: 1756-0381