Fig. 1

Illustration of disease modules with and without main disease gene. The size of the bubble reflects the effect size of the gene. When there is no main disease gene (as shown on the left), all disease genes have the same effect size. When there is a main disease gene (as shown on the right), the effect size of each disease gene is proportional to its closeness to the main disease gene within the module; the closer to the main disease gene, the larger the effect size