Fig. 4

Network-based plant polyphenols prioritization analysis approach predicts Genistein 10µM as the most effective polyphenol in targeting the MEK5/ERK5 pathway in breast cancer. A A summary of the analysis strategy employed in this analysis showing the key steps. Plant polyphenols proximal to the disease target MEK5/ERK5 network are identified using network proximity, gene ontology similarity and target gene orthogonality analysis and are prioritized based on their corresponding final scores. B Plant polyphenols ranked based on the scores obtained by summing network proximity score + GO Term similarity (Closest_Score + GOSIM) and/or network proximity score + GO term similarity + orthogonality score (Final Score)