Fig. 1

An illustration of the network-based pipeline for drug prioritization and combination analysis. The pipeline consists of two parts: A) Data acquisition from the literature and preprocessing to identify differentially expressed genes, and B) Network modelling illustrating the approach used to integrate differentially expressed genes from transcriptome data with the human protein–protein interaction network. These networks are then used as platforms to identify plant polyphenols proximal to the disease target network and approved drugs proximal to the plant polyphenol target network in the disease target network