Exploring active ingredients and function mechanisms of Ephedra-bitter almond for prevention and treatment of Corona virus disease 2019 (COVID-19) based on network pharmacology

Gao, Kai; Song, Yan-Ping; Song, Anna

doi:10.1186/s13040-020-00229-4

BioData Mining

Table 2 The information on potential targets of ephedra-bitter almond against COVID-19

From: Exploring active ingredients and function mechanisms of Ephedra-bitter almond for prevention and treatment of Corona virus disease 2019 (COVID-19) based on network pharmacology

No.	UniProt ID	Gene Symbol	No.	UniProt ID	Gene Symbol	No.	UniProt ID	Gene Symbol
1	P80404	ABAT	61	Q9NRD8	DUOX2	121	P01106	MYC
2	P33527	ABCC1	62	Q01094	E2F1	122	P14598	NCF1
3	Q9UNQ0	ABCG2	63	Q14209	E2F2	123	Q15788	NCOA1
4	Q13085	ACACA	64	P01133	EGF	124	Q15596	NCOA2
5	P22303	ACHE	65	P00533	EGFR	125	Q16236	NFE2L2
6	Q08462	ADCY2	66	P19419	ELK1	126	P25963	NFKBIA
7	Q15848	ADIPOQ	67	P04626	ERBB2	127	P35228	NOS2
8	P08913	ADRA2A	68	P21860	ERBB3	128	P29474	NOS3
9	P07550	ADRB2	69	P03372	ESR1	129	P15559	NQO1
10	P35869	AHR	70	Q92731	ESR2	130	O75469	NR1I2
11	O95433	AHSA1	71	P13726	F3	131	P08235	NR3C2
12	P31749	AKT1	72	P49327	FASN	132	Q9BZD4	NUF2
13	P09917	ALOX5	73	P01100	FOS	133	P11926	ODC1
14	P04114	APOB	74	P17302	GJA1	134	P09874	PARP1
15	P10275	AR	75	P49841	GSK3B	135	P12004	PCNA
16	Q92934	BAD	76	P00390	GSR	136	P06401	PGR
17	Q07812	BAX	77	P09488	GSTM1	137	P11309	PIM1
18	P10415	BCL2	78	P09211	GSTP1	138	P00750	PLAT
19	Q07817	BCL2L1	79	Q16665	HIF1A	139	P00749	PLAU
20	Q9BXY8	BEX2	80	P52789	HK2	140	P27169	PON1
21	O15392	BIRC5	81	P04035	HMGCR	141	P16435	POR
22	P00918	CA2	82	P09601	HMOX1	142	Q07869	PPARA
23	P42574	CASP3	83	Q00613	HSF1	143	Q03181	PPARD
24	P55210	CASP7	84	P07900	HSP90AA1	144	P37231	PPARG
25	Q14790	CASP8	85	P11021	HSPA5	145	P17252	PRKCA
26	P55211	CASP9	86	P04792	HSPB1	146	P05771	PRKCB
27	P04040	CAT	87	P05362	ICAM1	147	O43242	PSMD3
28	Q03135	CAV1	88	P01579	IFNG	148	P43115	PTGER3
29	P13500	CCL2	89	P01344	IGF2	149	P35354	PTGS2
30	P20248	CCNA2	90	P17936	IGFBP3	150	P06400	RB1
31	P14635	CCNB1	91	O14920	IKBKB	151	Q04206	RELA
32	P24385	CCND1	92	P22301	IL10	152	Q06455	RUNX1T1
33	P29965	CD40LG	93	P01583	IL1A	153	Q13950	RUNX2
34	P06493	CDK1	94	P01584	IL1B	154	P19793	RXRA
35	P24941	CDK2	95	P60568	IL2	155	Q14524	SCN5A
36	P11802	CDK4	96	P05112	IL4	156	P16581	SELE
37	P38936	CDKN1A	97	P05231	IL6	157	P05121	SERPINE1
38	O14757	CHEK1	98	P06213	INSR	158	P14672	SLC2A4
39	O96017	CHEK2	99	P10914	IRF1	159	P23975	SLC6A2
40	Q15822	CHRNA2	100	P05412	JUN	160	Q01959	SLC6A3
41	O15111	CHUK	101	Q12809	KCNH2	161	P31645	SLC6A4
42	O14493	CLDN4	102	P35968	KDR	162	P35610	SOAT1
43	P02452	COL1A1	103	P01130	LDLR	163	P00441	SOD1
44	P02461	COL3A1	104	P21397	MAOA	164	P10451	SPP1
45	P02741	CRP	105	P27338	MAOB	165	P36956	SREBF1
46	P17538	CTRB1	106	P11137	MAP2	166	P42224	STAT1
47	P07339	CTSD	107	P28482	MAPK1	167	P01137	TGFB1
48	P02778	CXCL10	108	Q16539	MAPK14	168	P07204	THBD
49	P19875	CXCL2	109	P27361	MAPK3	169	P01375	TNF
50	P10145	CXCL8	110	P45983	MAPK8	170	P11387	TOP1
51	P11511	CYP19A1	111	Q07820	MCL1	171	P11388	TOP2A
52	P04798	CYP1A1	112	Q00987	MDM2	172	P04637	TP53
53	P05177	CYP1A2	113	P08581	MET	173	P14679	TYR
54	Q16678	CYP1B1	114	O43451	MGAM	174	Q9HAW9	UGT1A8
55	P08684	CYP3A4	115	P03956	MMP1	175	P19320	VCAM1
56	Q96PD7	DGAT2	116	P08253	MMP2	176	P15692	VEGFA
57	P27487	DPP4	117	P08254	MMP3	177	P47989	XDH
58	P21728	DRD1	118	P14780	MMP9	178	P98170	XIAP
59	P14416	DRD2	119	P05164	MPO
60	P35462	DRD3	120	P55157	MTTP

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ISSN: 1756-0381

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