Fig. 1

Mango user interface. The main window is divided into four areas: data list (left), graph canvases (middle 3D visualizations), Gel editor (bottom left), and Gel command console (bottom right). Shown in the graph canvas area are the following networks: Left column: WGCNA correlation network, KEGG biological pathway network and their combined networks; Middle column: crown-plot of the intersection network between correlation and pathway networks and extracted hub genes sub-network; and Right column: hub and in-betweener genes laid out in a bipartite graph where nodes are labeled by gene names