Identification of genetic interaction networks via an evolutionary algorithm evolved Bayesian network

Table 2 Comparison of AUC for GEBN and logistic regression

	Functional SNPs in Case data	Functional SNPs in Control data	Weight (W)	MAX	Regression		GENN		GEBN
	Functional SNPs in Case data	Functional SNPs in Control data	Weight (W)	100	100	500	100	500	100	500
Main effect	SNP A	SNP A	0.1	55	52	51	54	54	53	52
			0.5	71	71	64	70	71	71	67
			0.9	88	88	72	88	88	88	87
	SNP A, B, C, D	SNP A, B, C, D	0.1	61	57	53	54	54	58	54
			0.5	90	89	72	73	73	89	87
			0.9	99	96	87	98	98	99	99
Interaction effect	SNP A * SNP B	None	0.1	53	50	50	50	50	50	50
			0.5	67	50	49	56	53	65	60
			0.9	89	50	50	60	59	80	77
	SNP A * SNP B	SNP W * SNP X	0.1	56	50	50	50	50	52	51
	SNP C * SNP D	SNP Y * SNP Z	0.5	82	50	50	57	55	81	67
	SNP C * SNP D	SNP Y * SNP Z	0.9	97	49	50	62	60	97	89

ISSN: 1756-0381