Table 5 Two-locus GxG interactions among 7 SNPs assessed by A-MDR

ATIC rs4673990+ MTHFD2 rs12196

3.9 (1.6–13.1)

0.001*

0.013*

1.9 (1.2-4.1)

0.001*

0.027*

6.1 (1.8-21.1)

<.001*

0.002*

ATIC rs4673990 + MTHFD2 5nt ins/16nt del

3.7 (1.5-12.8)

0.001*

0.013*

1.8 (1.1-3.6)

0.003*

0.032*

6.0 (1.6-22.0)

<.001*

0.002*

MTHFD2 rs12196 + GART rs8971

2.8 (1.1-8.8)

0.013*

0.069

1.6 (0.9-3.4)

0.016*

0.050

5.5 (1.3-20.7)

0.001*

0.009*

MTHFD2 5nt ins/16nt del + GART rs8971

2.6 (1.0-7.9)

0.017*

0.069

1.5 (0.9-2.7)

0.017*

0.050

5.0 (1.1-20.6)

0.002*

0.011*

ATIC rs4673990 + GART rs8971

2.5 (1.1-8.8)

0.027*

0.071

1.4 (0.9-2.4)

0.038*

0.088

4.7 (1.1-19.2)

0.009*

0.019*

ATIC rs2372536 + MTHFD2 5nt ins/16nt del

2.5 (1.0-8.3)

0.017*

0.069

1.6 (1.0-3.6)

0.006*

0.041*

5.0 (1.1-17.6)

0.011*

0.020*

ATIC rs2372536 + MTHFD2 rs12196

2.4 (0.9-8.0)

0.021*

0.069

1.4 (1.0-3.0)

0.033*

0.088

5.6 (1.2-18.3)

0.008*

0.019*

ATIC rs2372536 + GART rs8971

2.2 (0.8-6.5)

0.032*

0.074

1.5 (0.9-2.8)

0.015*

0.050

4.5 (0.8-28.2)

0.012*

0.020*

SLC25A32 rs17803441 +ITPA rs2295553

2.4 (0.8-7.5)

0.023*

0.069

1.6 (1.0-2.8)

0.013*

0.050

4.2 (0.8-17.9)

0.005*

0.019*

ATIC rs4673990 + SLC25A32 rs17803441

2.3 (0.8-8.2)

0.039*

0.081

1.4 (0.8-2.2)

0.061

0.106

4.9 (0.9-30.9)

0.009*

0.019*

MTHFD2 rs12196 + ITPA rs2295553

2.1 (0.9-7.1)

0.047*

0.090

1.4 (0.8-2.1)

0.065

0.106

4.2 (1.0-16.0)

0.025*

0.034*

ATIC rs4673990 + ITPA rs2295553

2.3 (0.7-7.1)

0.074

0.101

1.4 (0.7-2.2)

0.076

0.106

3.7 (0.9-13.2)

0.045*

0.059

MTHFD2 rs12196 + SLC25A32 rs17803441

2.2 (0.7-6.9)

0.060

0.097

1.4 (0.8-2.3)

0.067

0.106

5.2 (0.9-27.2)

0.012*

0.020*

ATIC rs2372536 + SLC25A32 rs17803441

2.2 (0.7-6.1)

0.056

0.097

1.3 (0.9-2.7)

0.062

0.106

6.6 (0.9-37.9)

0.008*

0.019*

MTHFD2 5nt ins/16nt del + MTHFD2 rs12196

2.0 (0.9-7.0)

0.074

0.101

1.3 (0.9-2.2)

0.088

0.115

5.2 (0.8-33.1)

0.008*

0.019*

MTHFD2 5nt ins/16nt del +LC25A32 rs17803441

2.0 (0.6-5.9)

0.077

0.101

1.3 (0.9-3.3)

0.073

0.106

4.2 (0.7-25.5)

0.015*

0.023*

MTHFD2 5nt ins/16nt del + ITPA rs2295553

1.9 (0.8-6.4)

0.114

0.139

1.3 (0.9-2.6)

0.129

0.160

3.9 (0.8-14.6)

0.076

0.094

ATIC rs2372536 + ITPA rs2295553

1.9 (0.8-6.9)

0.119

0.139

1.3 (0.9-2.2)

0.182

0.201

3.9 (0.8-13.3)

0.091

0.101

GART rs8971 + ITPA rs2295553

1.9 (0.8-8.9)

0.186

0.195

1.3 (0.9-3.6)

0.217

0.228

4.7 (0.8-16.1)

0.124

0.130

ATIC rs2372536 + ATIC rs4673990

1.8 (0.7-5.3)

0.131

0.145

1.2 (0.8-2.0)

0.161

0.188

4.0 (0.7-23.3)

0.089

0.101

GART rs8971 + SLC25A32 rs17803441

1.7 (0.4-9.9)

0.227

0.227

1.2 (0.7-5.7)

0.296

0.296

3.5 (0.4-19.1)

0.156

0.156