Figure 2
Examples of our methods for generating parameters for 2-locus pre-penetrance functions. Example A, illustrates the Sudoku method and examples B, C, and D illustrate the Point Method. The a’s (white boxes) are independent variables, or parameters, chosen by these two methods. The b’s (grey boxes) are dependent variables, specified in terms of the a’s, where the dark grey boxes highlight the last variables to be specified. The subscripts indicate one of many orders in which these dependences can be found. In A, the variables a 1, a 2and a 3are first chosen by the Sudoku method, then b 4and b 5are found in terms of these. After this, one of the four possibilities for a 6is selected. The remaining b’s are then found. In B, C, and D, the circled b’s represent example reference points for the Point Method.